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Nos experimentos, a equipe observou que os animais mantidos em dietas com alto teor de sal tinham mais chance de desenvolver uma doença autoimune. Foi preciso um comparsa – no caso, a injeção nos roedores de uma substância (autoantígeno) que induzia um quadro autoimune nos animais, como se esse animal passasse a ter uma predisposição à doença.

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O propósito inicial da equipe era entender como o organismo controla o sistema imune, exercendo aquela sintonia fina que permite que ele não descambe nem para um lado (imunidade baixa), nem para outro (imunidade exacerbada).

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