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She broke ground with a multi-racial cast, same sex couples, and one of TV’s first bi-sexual characters.

The series has survived multiple cast changes, the behind-the-scenes drama the often eclipsed the on-screen shenanigans and fickle fans who threatened to quit the show when Mc Dreamy (Patrick Dempsey) died.

Amanda Schurr Netflix’s new animated series, from creators Nick Kroll, Andrew Goldberg, Jennifer Flackett and Mark Levin, follows four friends through the earliest stages of puberty: Andrew (John Mulaney) sports inconvenient erections; Nick (Kroll) awaits his first pubic hairs; Jessi (Jessi Klein) begins menstruating at the Statue of Liberty; Jay (Jason Mantzoukas) conceives rococo ways to get off with his pillow.

It’s wickedly bawdy—one episode’s end credits roll over an extended description of Andrew’s dad’s testicles—and devilishly funny—another uses a note-perfect Seinfeld send-up to explain the blowjob “head push” and the term “mons pubis”—but as implied by its theme song, Charles Bradley’s “Changes,” the series is sweeter than it appears at first blush.

As wacky and over-the-top as Sense8 can often get, the series remains important as it deals with issues of sexuality and gender identity through the work of trans actress Jamie Clayton and performers Miguel Silvestre and Alfonso Herrera’s portrayal of a gay couple in Mexico City. Luke Cage is obviously a Marvel product, but it’s also the product of its creator, Cheo Hodari Coker, and its cast, including Mike Colter, Mahershala Ali, Alfre Woodard, Simone Missick, and Erik La Ray Harvey (plus appearances by Frankie Faison, Ron Cephas Jones and, of course, Method Man): The series has more flexibility in addressing its subject matter thanks to its platform, but it’s hard to imagine that it’d speak as loudly or as boldly even on Netflixwithout Coker driving the narrative forward.

Robert Ham You probably don’t have to be a bookworm, or a kid, to appreciate this adaptation of a series of ironic, lachrymose, self-parodying children’s stories, because the series is just so damn funny, not to mention seamlessly styled, well-cast and well-acted. Even though he stumbles during the show’s midsection, his errors don’t add up to more than an inconvenience: Luke Cage blends its source material with a wide range of influences, from jazz to rap to horrors ripped straight from the headlines, and churns out a yarn that’s as powerful as it is irresistibly poppy.

By admitting, as Andrew does in the series premiere, that “everything is so embarrassing”—and not only for teens—Big Mouth squares a space in which there’s no question that can’t be asked, and no answer that applies the same way to everyone.

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are more and more of the streaming platform’s own original series.

Premiering as a mid-season replacement way back in March 2005, Grey’s, now in its thirteenth season, first appeared to be nothing more than an ER wannabe.

But Rhimes perfected the art of a well-told soap opera, seamlessly weaving personal strife, romantic hookups (never have supply closets seen so much action) and complex medical cases.

Grey’s is my ultimate comfort-food TV, and I bet it will become yours too. Jane the Virgin Creator: Jennie Snyder Urman Stars: Gina Rodriguez, Justin Baldoni, Yeal Grobglas, Jaime Camil, Andrea Navedo, Ivonne Coll, Anthony Mendez Network: The CW A virgin perfectionist with a heart of gold shouldn’t be this watchable.